Y Combinator Spring 2026 companies

The personal AI agent that keeps up with your work and life.

The P&L for knowledge work

Human experts as API for AI Agents

Emotive foundation voice models

Consumer simulations for CPG market research

AI-native ERP for manufacturers

Programmable DNA drug destroying all cancers, unlocking 80% of targets

AI-native recruiting agency

Make your product AI native by tomorrow.

Ploy turns your website into your company's growth engine.

Machine intelligence for American Welding

Team chat to command all your company's coding agents

AI primary care doctor

Adaptive training coach for runners, cyclists, and triathletes

Vanta for hardware

AI Customer Support for Fortune 500-scale enterprises

Design your home instantly with AI

Counter Drone Systems. $1.6m sales. We delivered for the DoW.

The AI-native observability platform for fast-moving engineering teams

AI agents for data science (enterprise)

Building self-improving software

Monitor and fix product privacy issues before they block growth

Automating Corporate Compliance, Worldwide

The brand layer for agents.

Satellites for Manufacturing in Space

AI-Native insurance company

The hardware-agnostic operating system for drone defense

AI Agent for Therapists

Your Capable Desktop AI Companion

communication for agents

Hedge fund where AI researches and executes every trade end-to-end

Code review platform for humans and agents

Robotics

Everything your team ships, explained to everyone it affects.

Agent harnesses for asset managers

derivative layer for prediction markets

Run any coding agent harness in the cloud

AI Takeoffs for Concrete

Autonomous operations for industrial distributors

We help software companies get discovered and used by AI agents

Humanoid robot platform for builders.

Software factory for product teams

AI scientists to discover materials for the semiconductor industry.

Helping your company find 10x engineers.

iMessage infrastructure for business

RF test equipment for next-gen spacecraft, drones, and cellphones

The browser for agentic development

Robotic arms that pick and pack your orders.

AI Scheduling for Short Haul Trucks

Agents that run short-term rental operations end-to-end

AI Agents for Analog Circuit Design

AI-automated factory for PCBAs

Real-world training data for frontier AI labs and robotics.

AI-run consumer brands

Extend cloud sandboxes with iOS, Android and more

Make software self-healing

Automating Government Workflows, starting with FOIA

Autonomous insurance brokerage for small businesses

AI Health Assistant for Chronic Illness

AI Back-Office Automation for Commercial Lenders

AI model built for high accuracy deterministic tasks

AI Reservation System for Restaurants

AI-native platform for wealth managers

Cross-border payments for exporters of physical goods.

The AI Quant: Autonomous Alpha Engine for Funds and Traders.

Collaborative AI app builder for teams

AI Event Manager for in-person events

Hyper-efficient coolers for data centers

Annotations for robotics data

Agentic hiring marketplace

Measure freight with security cameras

Let agents talk to your customers

Make websites improve themselves.

Autonomous research agents for R&D and applied science

Scale marketing campaigns across hundreds of personas

Marketplace for AI agents to hire humans.

Agents that build personal injury cases

Real-world sandboxes to test and train AI agents

staffing firms with dreach grow revenue faster.

robots & software for farms

AI voice agents for on-prem telephony stack.

AI mobile app that helps factory technicians fix broken machines

Autonomous medical billing

Building the Data Infrastructure layer for Physical AI.

Live Evaluation Arenas for Financial Work

Near-real-time video infrastructure for LLMs

Monitoring and learning layer for long-running agents

AI FDEs to make your B2B SaaS Go Live in Days, not Months

AI Go-To-Market agents for B2B teams

AI nutrition coach in your pocket

AI agents that interviews every employee to hand context to AI tools.

Institutional infrastructure for prediction markets

The agentic OS for medical labs

Bring AI to life with the world's best interactive avatars

Company brain every AI-native enterprise runs on

Cancer screening without barriers

Fast, smart, accessible 3D ultrasound that anyone can use

Autonomous manufacturing for mechanical parts

Where new internet entrepreneurs build and run their companies

Agentic operating system for auto repair shops

The AI Agent Insurance Carrier

Control lab instruments with natural language.

Submarine drones for defense

Vanta for physical products

Building AI Native Customs Brokerages

AI-native CRO for clinical trial operations

The spend control layer for AI agents

Ship software faster with portable, self contained virtual machines.

Prime brokerage for prediction markets

Working capital for data companies training frontier AI

Scalable windows desktop automations

Camera-free AI glasses. Your AI, out in the world.

AI that turns your product into on-brand marketing content

Deployment infrastructure for Physical AI

ValCtrl is building the only intelligent prediction market

Reason Machines builds Reason Agent, the autonomous software engineer…

Distributed runtime for AI workloads at scale

Construction Cost Intelligence.

We get your product picked by coding agents.

AI Financial Research Terminal built for Healthcare (and beyond)

Robotic pitstops for self-driving cars

AI Employee for Manufacturing Operations

Staging Environments for Enterprise AI Agents

Agents that own the work

The control point for AI agents at work.

AI coworker for marketing teams at the largest consumer brands

Database sandboxes for Agents

Real world training envs for healthcare AI models

Security for agents that self-improves

Create & play AI games with friends

AI Native Sourcing Broker For Overseas Manufacturing

Company Brain.

The Intelligence layer for Drug Manufacturing

The first wearable that reads your emotions to enhance your EQ.

We're building robot birds for surveillance.

AI water leak detection for buildings

The AI-native McKinsey

Autonomous services for humanity.

Test your app with AI, catch bugs before users do

Plena is the AI operating system for specialty medical practices

Autonomous Runtime Security

Forward-deployed AI Agents

AI Native Shopify

Automating open-ended research.

An open-source operating system for reliable long-running agents

Fixing air traffic control with remote towers

We make the most compact nuclear reactors

The open source alternative to Claude Cowork

Tolmo is the AI security platform that secures every layer of cloud…

Agent native workspace for heavy parallel workflows on the web

Simulations of real people for market research

The autonomous ERP for every manufacturer

The control plane for agent-native work.

Computer use agents to deploy enterprise marketing campaigns

Unlock wasted GPU capacity.

Patreon for AI Originals

The AI agent harness for payment teams

The AI revenue platform for D2C brands

Agents that move money, trade stocks, and file taxes.

Phone Numbers for AI Agents

AI-native internal audit firm

The AI mobile wallet that replaces Apple Pay

Your AI growth hire.

AI recruiters for staffing agencies

US stock trading, unlocked for the globe

The human-in-the-loop system for robots

AgentRel — Devrel For Agents

Monitoring and governance for deployed medical imaging AI

AI Operating System for Clinical Development

Track drones and missiles without radars - Accurate, Passive, Scalable

Find and engage with desperate buyers across LinkedIn, Email, and X

AI implementation firm that maps and automates business processes

Liability insurance for AI Agents. You deploy agents, we cover you.

Kugel is an on-prem Voice AI model supporting 30+ languages

AI agent platform for home services companies.

AI-Native FDA Regulatory Services

Modern - the ServiceNow killer

Specialized models that make your AI agents cheaper and more reliable.

The agent-native serverless cloud

Company brain that powers your AI employees

The AI Workforce for Biopharma

AI-native credentialing and contracting for healthcare

AI-native patient engagement

The Authorization Layer for AI Agents

Human Intelligence for Robots

Automated LiveOps for Game Studios

Modern Intelligence for Finance

The first AI founder: a virtual human who runs his own companies.

AI-native actuary enabling self-insurance for corporations

A personal or team assistant that works while you sleep

The simplest interface in the world to talk AI models + spawn agents

Autonomous Customer Operations